Acute liver impairment after sodium valproate overdose

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Acute liver impairment after sodium valproate overdose.

Liver impairment is a recognised adverse effect of long-term sodium valproate treatment, but there are few reports concerning its occurrence after acute overdose. This report describes a 36-year-old woman who deliberately ingested 32 g of sodium valproate (Epilim). Serum valproate concentration was 4370 μmol/l (630 mg/l) at 4.3 h post-ingestion (therapeutic reference range: 300-600 μmol/l), and...

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The consequences of valproate overdose.

A 43-year-old man with epilepsy who had been treated with valproic acid (Depakote®) (VPA) for 13 years and had a history of multiple suicide attempts and alcohol dependence presented after ingesting an overdose of VPA and ibuprofen. The patient was not on any other prescribed medications. At presentation, the patient exhibited the following: Glasgow Coma Score (GCS), 3/15 (3 being the worst, in...

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ژورنال

عنوان ژورنال: Case Reports

سال: 2009

ISSN: 1757-790X

DOI: 10.1136/bcr.06.2008.0057